TADALAFIL (DAILY) BENEFITS
Long-term health beyond ED
- In clinical trials, Tadalafil was shown to reduce heart disease risk up to 60% by improving blood flow and circulation.¹
- Evidence also suggests that Tadalafil may reduce Alzheimer’s risk up to 44% by boosting blood flow to the brain.²
- By boosting blood flow, Tadalafil may also enhance oxygen and nutrient delivery to organs, reducing the risk of diseases like atherosclerosis.³
- When taken as needed, Tadalafil is FDA approved to treat ED and enlarged prostate for men.
- When taken daily, Tadalafil may improve cardiovascular function, brain health, and inflammation for men and women.⁴
¹Cardio Drugs Ther, 2021 ²Neurology, 2024 ³J S Med, 2022 ⁴AMJM, 2024
See the ScienceHow does Tadalafil work?
A science-backed approach to longevity
- Tadalafil is a PDE5 inhibitor that blocks the protein responsible for regulating cGMP, the molecule that regulates healthy circulation, brain function, and blood vessel widening.¹
- cGMP, or cyclic guanosine monophosphate, stimulates blood flow to organs throughout the body, hence its success for treating ED when taken as needed.²
- As we age, our cGMP levels decline, contributing to compromised organ function, ED, chronic inflammation, and age-related diseases.³
- By blocking PDE5, research shows that Tadalafil helps restore cGMP to youthful levels, protecting against age-related decline for both men and women. ⁴
¹Pharmacy & Therapeutics, 2013 ²J Clin Hypertens, 2006 ³J Cardio Pharm, 2021 ⁴Am J Physiol, 2010
Emerging research on Tadalafil’s longevity benefits
When taken daily, multiple clinical studies provide convincing evidence of Tadalafil’s added health and longevity benefits:
- Improves cognitive function and mental clarity
- May increase lifespan by enhancing blood flow to major organs
- Reduced all-cause mortality by 44% in clinical trials
- Boosts anti-cancer immunity by improving cellular health
- Protects against Alzheimer’s by boosting blood flow to the brain
- Reduces risk of heart disease by enhancing endothelial function
- Lowers inflammation—a key hallmark of aging—by increasing cGMP levels
Tadalafil (generic Cialis) has not been approved by the FDA for these longevity uses, but there are multiple studies that have shown potential longevity benefits.
What the Tadalafil science says
There is a fundamental reason to consider PDE5 inhibitors as anti-aging medicines (in both men and women). The key word is “relax”. Senescent cells are tense and stressed. Cellular senescence is manifested by hyper-function. On the organism levels hyper-function is translated in hypertension, hyperplasia, hyperlipidemia and so on. By ‘relaxing the tension’, PDE5 inhibitors may slow senescent-associated pathology [causing] anti-vasoconstriction, anti-proliferative and anti-inflammatory effects.
From Rapalogs to Anti-Aging FormulaOncotarget (2017)
Tadalafil possesses antioxidant as well as anti-inflammatory action associated to an improvement in attention and coordination functions… Erectile dysfunction is [also] commonly associated with depression, and treatment with PDE5 inhibitors [Tadalafil] improves cognitive functions and depression, in addition to erectile dysfunction. Therefore, treatment of BPH/LUTS-ED with Tadalafil could improve patients’ quality of life and their cognitive functions.
Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity of Patients With Low Urinary Tract SymptomsSci Rep (2019)
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- $2.33 / tab
- 1 tab daily for consistent longevity support
- 2.5 or 5mg daily dose, as prescribed
- FREE shipping & on-demand prescriber support
- Discreet packaging
CODE TADALAFIL10: $10 off first month & FREE medical evaluation
- $2 / tab
- 1 tab daily for consistent longevity support
- 2.5 or 5mg daily dose, as prescribed
- FREE shipping & on-demand prescriber support
- Discreet packaging
CODE TADALAFIL25: $25 off first quarter & FREE medical evaluation
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Doctor may recommend a different dose during medical intake process
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* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
FAQs
How do I take Tadalafil?
When taking Tadalafil for longevity purposes, you will take a single Tadalafil tablet (2.5 or 5 mg, as prescribed) with a glass of water at any time—day or night, with or without food.
What are the benefits of taking Tadalafil daily versus as needed?
Taking Tadalafil daily at a lower daily dose (2.5mg or 5mg) reduces many common side effects and allows the freedom to be intimate on your own time without having to plan ahead.
The benefits go far beyond sexual health. When taken daily over the course of many years, Tadalafil may offer numerous longevity-enhancing benefits. Recent clinical research suggests that Tadalafil’s ability to improve blood flow may reduce the risk of heart disease and even lower the risk of dementia. These benefits stem from Tadalafil’s primary mechanism of action of improving blood flow.
As-needed tadalafil is dosed at 10mg and 20mg typically, but should only be taken no more frequently than once every 3 days. These higher, less-frequent doses are only used for erectile dysfunction in men and are not expected to have much in the way of longevity benefits.
What are the longevity benefits of Tadalafil?
Anti-aging benefits: A clinical analysis cited PDE5 inhibitors, such as daily Tadalafil, as a worthwhile addition to any “anti-aging drug mixture because ED and BPH are most prevalent age-related conditions in aging men.” Furthermore, the analysis states that by “relaxing the tension [in senescent cells] may slow senescent-associated pathology… causing anti-vasoconstriction, anti-proliferative and anti-inflammatory effects.”
Reducing health risks related to aging: The same clinical analysis cited above suggests that by fighting against cellular senescence, PDE5 inhibitors, such as Tadalafil, may also help to reduce health risks related to aging, such as heart hypertrophy, myocardial infarction, cancer, neurodegenerative diseases, cystic fibrosis, diabetes, obesity and metabolic syndrome.
Anti-inflammatory properties: Another clinical study in Scientific Reports concludes, “chronic inflammation plays an important role in BPH/LUTS (lower urinary tract symptoms) and contributes to the clinical progression of BPH-related symptoms… Tadalafil, but not sildenafil or vardenafil, reduces pro-inflammatory factors.”
Improved cognitive function: In this clinical study, researchers state: “Erectile dysfunction is commonly associated with depression, and treatment with PDE5 inhibitors improves cognitive functions and depression, in addition to erectile dysfunction. Therefore, treatment of BPH/LUTS-ED with Tadalafil could improve patients’ quality of life and their cognitive functions.”
Improved heart health: A BMJ study found that PDE5 inhibitors, such as Tadalafil, “improved contractile function, reduced chamber dilatation and reduced LVH.” In other words, keeping the heart rate normal, increasing blood flow and the ability for the heart to supply the body with enough blood, and reducing blood pressure to decrease the heart’s workload.
See all FAQsImportant safety information and common side effects
As with any drug product, there may be side effects. Generally, patients who experience side effects usually get them within 12 to 24 hours after taking Tadalafil. Side effects usually resolve on their own within 48 hours. Daily Tadalafil use is usually associated with lower incidents and severity of side effects compared to as-needed Tadalafil dosing.
Most common Tadalafil side effects
- Headache
- Indigestion
- Back pain
- Muscle pain
- Flushing
- Stuffy nose
Some more serious side effects have been reported. While rare, it is important to stop taking Tadalafil and contact a doctor right away if any of the following occur:
- An erection will not go away (priapism). If you have an erection that lasts longer than 4 hours, get medical help right away. If not treated right away, priapism can permanently damage the penis.
- Sudden vision loss in one or both eyes. Sudden vision loss can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropath (NAION).
- Sudden hearing decrease or hearing loss. Some may also have ringing in the eyes (tinnitus) or dizziness.
For a complete list of possible side effects, click here.
Possible drug interactions
Some drugs/medications may interact with Tadalafil. You should not take Tadalafil if you are taking nitrates (such as nitroglycerin tablets or patches) because the combination of these with Tadalafil could significantly lower blood pressure and lead to fainting or even death. Additionally, do not take Tadalafil if you are taking Cisapride, other ED medications (e.g. Viagra), Adcirca, or Riociguat.
On your intake form, please be sure to provide AgelessRx with all medications, herbs, non-prescription drugs, or dietary supplements you use. Also be sure to report if you smoke, drink alcohol, or use illegal drugs, as some may interact with your medication.
For a complete list of possible drug interactions, click here.
Other important safety information
Patients who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may get side effects such as fainting or light-headedness. Because patients with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye problems have not been studied, Tadalafil (Cialis) is not recommended for these patients. There may be rare occurrences of priapism or painful, prolonged erections. This is a serious condition that requires immediate medical attention. Patients should seek prompt medical attention if their erection lasts longer than four hours.
After taking a single tablet, Tadalafil can remain in the body for up to two days. It can remain longer if patients have problems with their kidneys or liver, or they are taking certain other medications.
Note: All information included on this page is a summary. It may not cover all possible information. If you have questions about this medication, talk to a doctor, pharmacist, or healthcare provider.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.